Molecular Glues, tiny adhesives

---

Protein-protein interactions reach a new level with molecular glues, as these small molecules have the incredible ability to selectively bind to multiple proteins, acting as a “glue” between them. Molecular glues are similar to PROTACs as they can bind proteins for inducing degradation. However, molecular glues have the advantage of inducing a variety of biological outcomes, including protein degradation, protein stabilization, and protein conformational changes. 

Molecular glues have diverse applications across various fields, including oncology, immunology, and neurobiology. In cancer research, molecular glues hold promise for targeting protein complexes involved in tumor growth and metastasis. Molecular glues also have potential therapeutic implications in neurodegenerative disorders by modulating protein aggregation processes associated with diseases like Alzheimer's and Parkinson's.